Pharmaceutical Technology
- FAR 121/4: Microbiology for pharmacy (coordinator)
- FAR 247/2 – Biopharmaceutical II (coordinator)
- Pulmonary drug delivery for respiratory infections, i.e. tuberculosis, pneumonia and cystic fibrosis:
- Polymeric microparticles and nanoparticles
- Dry powder and liquid formulations
- Device strategies
- Pulmonary toxicity
- Discovery of potential anti-mycobacterial and anti-microbial agents
Pulmonary drug delivery and microbiology
Publications in the last 3 years
- Parumasivam T, Ashhurst AS, Nagalingam G, Britton WJ, Chan H-K. Inhalation of respirable particles induces pulmonary inflammation. Mol Pharm. 2017; 14:328-335.
- Parumasivam T, Chang RYK, Abdelghany S, Ye TT, Britton WJ, Chan H-K. Dry powder inhalable formulations for anti-tubercular therapy. Adv Drug Deliv Rev. 2016;102:83-101.
- Parumasivam T, Chan JGY, Pang A, Quan DH, Triccas JA, Britton WJ, Chan H-K. In vitro evaluation of inhalable verapamil-rifapentine particles for tuberculosis therapy. Mol Pharm. 2016;13:979-89.
- Parumasivam T, Leung SSY, Quan DH, Triccas JA, Britton WJ, Chan H-K. Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: preparation and in vitro aerosol characterization. Eur J Pharm Sci. 2016;88:1-11.
- Parumasivam T, Chan JGY, Pang A, Quan DH, Triccas JA, Britton WJ, Chan H-K. In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. Eur J Pharm Biopharm. 2016;107:205-214.
- Parumasivam T, Leung SSY, Tang P, Mauro C, Britton W, Chan H-K. The delivery of high-dose dry powder antibiotics by a low-cost generic inhaler. AAPS J. 2016;1-12.
- Leung SS, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan H-K. Production of inhalation phage powders using spray freeze drying and spray drying techniques for treatment of respiratory infections. Pharm Res. 2016; 33:1486-96.
- Li L, Sun S, Parumasivam T, Denman JA, Gengenbach T, Tang P, Mao S, Chan H-K. L-leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders. Eur J Pharm Biopharm. 2016; 102:132-41.
- Leung SS, Parumasivam T, Tang P, Chan H-K. A proof-of-principle setup for delivery of Relenza® (Zanamivir) inhalation powder to intubated patients. J Aerosol Med Pulm Drug Deliv. 2015: 29.
- Zhou QT, Leung SS, Tang P, Parumasivam T, Loh ZH, Chan H-K. Inhaled formulations and pulmonary drug delivery systems for respiratory infections. Adv Drug Deliv Rev. 2015; 85:83-99.
Presentations at conferences and meetings in the last 3 years
- Parumasivam T, Chan JGY, Quan DH, Pang A, Triccas JA, Britton WJ, Chan H-K. In vitro evaluation of inhalable thioridazine-rifapentine particles for rapid tuberculosis therapy, in: 1st Asia Pacific AIDS & Co-infections Conference, Hong Kong, 2016.
- Parumasivam T, Ashhurst A, Britton WJ, Chan H-K. Assessing murine immune response to pulmonary delivery of crystalline rifapentine particles, in: 2016 CRS Annual Meeting, Seattle, Washington, U.S.A, 2016.
- Leung SS, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan H-K. Production of inhalable phage powders for treatment of respiratory infections, In 2015 Year of The Phage Conference, San Diego, USA.
- Parumasivam T, Chan JGY, Pang A, Quan DH, Triccas JA, Britton WJ, Chan H-K. In vitro evaluation of inhalable verapamil-rifapentine particles for rapid tuberculosis therapy, in: 15th Asia Pacific Congress of Clinical Microbiology and Infection Kuala Lumpur, Malaysia, 2014.
- Parumasivam T, Leung SSY, Quan DH, Triccas JA, Britton WJ, Chan H-K. In vitro evaluation of rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy, in: The 8th International Conference on Materials Science and Technology, Bangkok, Thailand, 2014.
- Leung SSY, Parumasivam T, Mauro C, Chan H-K. A modified Aerolizer® for delivery of high dose dry powder therapeutics, in: Respiratory Drug Delivery (RDD®), Fajardo, Puerto Rico, 2014.
