• Banner PPSF USM

  • web covid1

  • Web Banner Covid 1

  • Presentation3.png

  • QS_ranking_by_subject.png

  • QS_ranking_banner.png

  • ICPHS_banner.png

  • No one shall enter the laboratories unless entry permission is granted.

Vikneswaran a/l Murugaiyah

vickneswaran1

Vikneswaran a/l Murugaiyah, Dr.
Senior Lecturer
B Pharm (Hons)(USM),
Ph.D.(USM)
J01 Room 113
School of Pharmaceutical Sciences
Tel : 604-6577888 Ext. 4149
Email : vicky@usm.my

Discipline


Pharmacology

Courses taught


  1. Semester I
    • FAR 341/4                   Respiratory, Renal & Blood System and Therapy
                                          (lecture & practical)
    • FAR 342/3                   Cardiovascular System and Therapy
                                          (practical)
  1. Semester II
    • FAR 142/3                   Basic Pharmacology and Biochemistry
                                          (practical)
    • FAR 141/4                   Peripheral Nervous System and Therapy
                                          (practical)
    • FAR 242/4                   Endocrine System and Metabolism
                                          (lecture)
    • FAR 344/4                   Central Nervous System and Therapy
                                         
      (lecture & practical; also the course coordinator)

Research Interest


Drug discovery from natural products and synthesized organic compounds for neurodegenerative, metabolic and infectious diseases.

Expertise

Pharmacology, Phytochemistry, Analytical chemistry, Drug discovery

Consultation

  • Analytical studies: Including development and validation of analysis methods, including phytochemical analysis of marker compounds and standardization of herbal extracts
  • Animal studies: Pharmacological studies, acute, sub-chronic and chronic toxicity studies in mice, rats and rabbits
  • In vitro and ex vivo testing: antimicrobial studies, enzyme inhibitory studies, antioxidant studies
  • Pharmacokinetics testing: Bioavailability and pharmacokinetic studies of natural  products or synthetic compounds

Selected Publication

(a) International Journals

 

i.   Murugaiyah, V. and Chan, K.L. (2006) Antihyperuricemic lignans from the leaves of Phyllanthus niruri L. Planta Medica. 72, 1262-1267.

ii.  Murugaiyah, V. and Chan, K.L. (2007) Determination of four lignans in Phyllanthus niruri by a simple HPLC method with fluorescence detection. Journal of Chromatography A. 1154, 198-204.

iii.  Murugaiyah, V. and Chan, K.L. (2007) Analysis of lignans from Phyllanthus niruri L. in plasma using simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. Journal of Chromatography B. 852, 138-144.

iv.   Murugaiyah, V. and Chan, K.L. (2009) Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of Ethnopharmacology. 124, 233-239.

v.   Parthasarathy, S., Ramanathan, S., Ismail, S., Adenan, M.I., Mansor, S.M. and Murugaiyah, V. (2010) Determinationof mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat. Analytical and Bioanalytical Chemistry. 397, 2023-2030.

vi.   Krishnan, N., Ramanathan, S., Sasidharan, S., Murugaiyah, V. and Mansor, S.M. (2010) Antimicrobial activity evaluation of Cassia spectabilis leaf extracts. International Journal of Pharmacology. 6(4), 506-510.

 

(b) Local Journals

 

i.    Murugaiyah, V. and Chan, K.L. (2005) Xanthine oxidase inhibitory activity of some Malaysian plants. Malaysian Journal of Science. 24, 263-266.

ii.   Kuong, Y.M., Sadikun, A., Murugaiyah, V. And Asmawi, M.Z. (2010) Determination of Flavonoids and chlorogenic acid in Gynura procumbens by a simple high performance liquid chromatography method with ultraviolet detection (HPLC-UV). Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 9-10.

iii.   Beh, H.k., Seow, L.J., Asmawi, M.Z., Majid, A.M.S., Murugaiyah, V., Ismail, Z and Ismail, N. (2010) Antiangiogenic activity of Morinda citrifolia extracts and its chemical constituents. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 10-11.

iv.   Seow, L.j., Beh, H.K., Majid, A.M.S., Murugaiyah, V., Ismail, N. And Asmawi, M.Z. (2010) Antiangiogenic activity of Gynura segetum leaf extracts and its fractions. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 32.

v.   Koay, Y.H., Murugaiyah, V. And Chan, K.L. (2010) Evaluation of cholinesterase inhibitory activity of Phyllanthus niruri. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 44.

vi.   Aruldass, C.A., Ramanathan, S., Mansor, S.M. and Murugaiyah, V. (2010) Antimicrobial activity of methanolic extrcats of various parts of Mesua ferrea. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 45.

vii.  Marimuthu, M.M.,  Mansor, S.M., Murugaiyah, V. and Ramanathan, S. (2010) Antimicrobial activity of methanolic extracts of various parts of Ixora coccinea. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 46.

viii.  Lee, Y.E., Murugaiyah, V. and Chan, K.L. (2010) Acetylcholinesterase and butyrlcholinesterase inhibitory activities of Ailanthus malabarica and its fractions: A source for potential anti-alzheimer’s drugs. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 55-56.

ix.    Liew, W.L., Murugaiyah, V. and Chan, K.L. (2010) Inhibitory activities of Andrographis paniculata and its fractions on acetylcholinesterase and butyrlcholinesterase enzymes: A source for potential anti-alzheimer’s drugs. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 56-57.

x.    Noormi, R., Subramaniam, S., Murugaiyah, V. and Sundarasekar, J. (2010) Qualitative determinations of potential lycorine alkaloid in Hymenocallis littoralis (Melong Kecil). Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 74.

xi.   Sandrasagaran, U.M., Ramanathan, S., Subramnaniam, S., Mansor, S.M. and Murugaiyah, V. (2010) Antimicrobial activity of Dendrobium crumenatum (Pigeon Orchid). Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 111-112.

Current Research

  1. Studies on the mechanisms of antihyperuricemic activity, chronic toxicity and formulation of Phyllanthus niruri lignans for the development of potential antihyperuricemic agents.

  2. Cholinesterase inhibitors from Andrographis paniculata and Phyllanthus niruri and their effects on memory and learning of the rodents.

  3. Antihyperlipidemic and antioxidant activity of different parts of Garcinia atroviridis and elucidation of their mechanisms of action

  4. Antihyperlipidemic and antioxidant of different parts of Garcinia mangostana

  5. Cholinesterase inhibitors from Garcinia mangostana and their effects in Aß-induced neurotoxicity and on memory of the rodents.

 

News Highlight

Appeal for Re-checking of Exam Results

RAYUAN PENYEMAKAN SEMULA KEPUTUSAN PEPERIKSAAN PEPERIKSAAN SEMESTER PERTAMA, SIDANG AKADEMIK 2021/2022 Program Pengajian Ijazah Tinggi Program Pengajian Ijazah Pertama (Penuh Masa & Program Pesisir) Program Diploma Tempoh permohonan rayuan penyemakan semula keputusan peperiksaan bagi Peperiksaan Semester Pertama, Sidang Akademik 2021/2022 adalah daripada 31 MAC 2022 hingga 29 APRIL 2022. Untuk...

Course Registation for Year 2021/22 Sem 2 is now open

Course Registation for Year 2021/22 Sem 2 is now open

Adalah dimaklumkan bahawa aktiviti pendaftaran kursus penuh masa (termasuk kursus bahasa) dilakukan secara berperingkat mengikut tahun pengajian pelajar seperti berikut: Untuk maklumat lanjut, lihat sini. Please be informed that the registration of full-time courses including language classes for undergraduate students will be open in phases according to year of study...

USM Synchronouns Online Exam Briefing and Mock Exam

USM Synchronouns Online Exam Briefing and Mock Exam

Attention to students who are involved in USM Synchronous Online Exam, please mark your calendars for exam briefing and mock exam.   Briefing: Date: 24 Jan 2022 Time: 9.30am - 10.30am Link : https://youtu.be/IXT_Phhmv0Q   Mock Examination Date: 24 Jan 2022, 11.00am till 31 Jan 2022, 6.00pm Link: https://examtrial.usm.my

Pharmaceutical Compounding I Microcredential Module is now open for registration

Pharmaceutical Compounding I Microcredential Module is now open for registration

A new microcredential module is up and ready from the School of Pharmaceutical Sciences USM! This module, Pharmaceutical Compounding I is specially prepared for pharmacists, assistant pharmacists, pharmacy students and pharmacy assistants in community pharmacies, and focuses on the background and general introduction on compounding and the requirement that need...

Appeal for Re-checking of 'Kursus Semasa Cuti Panjang (KSCP)' Exam Results, AY 2020/2021

Appeal for Re-checking of 'Kursus Semasa Cuti Panjang (KSCP)' Exam Results, AY 2020/2021 Postgraduate programmes Undergraduate programmes Diploma programmes Deadline: 7 - 21 October 2021 For more information, please see here. Download application form here.  Rayuan Penyemakan Semula Keputusan Peperiksaan bagi Peperiksaan Kursus Semasa Cuti Panjang (KSCP), SA 2020/2021  Program Pengajian Ijazah...

For_visitors.png    elearn_usm.png     Campus_online.png     Facebook_page.png     For_alumni.png