Roziahanim Mahmud
BSc (Chemistry) Sonoma State University, California USA.
MSc (Chemistry) California State University, Long Beach, California USA.
PhD (Pharmacology) University of Liverpool, UK.
J02 Room 133
School of Pharmaceutical Sciences
Tel : 604-6577888 Ext. 2209
Email : rozi@usm.my
2. Tingle MD, Mahmud R, Maggs JL, Pirmohamed M, Park BK. Comparison of the Metabolism and Toxicity of Dapsone in Rat, Mouse and Man. Journal of Pharmacology and Experimental Therapeutics (1998), 283 (2): 817 – 823. 3. Tingle MD, Mahmud R, Maggs JL, Hawley S, Coleman MD, Ward SA, Park BK. The Effect of 2,2-Substitution on the Metabolism and Toxicity of Dapsone in-vitro and in-vivo. Environmental of Toxicology and Pharmacology (1998), 5 (1): 145 – 153. 4. O’Neil PM, Tingle MD, Mahmud R, Storr RC, Ward SA, Park Bk. The Effect of Fluorine Substitution on the Haemotoxicity of Primaquine. Bioorganic and Medicinal Chemistry Letters (1995), 5(1): 2309 – 2314. Phytochemical and pharmacological studies of local medicinal plant bioactives. Determination of the bioactive components of plant species that involves methods of extraction, isolation, separation, purification and chemical characterisation of the plant phytochemicals and their related anti-cancer, anti-malarial and anti-microbial bioactivities. Studying the metabolism based-toxicity of drug molecules or herbal constituent and their underlying mechanisms of action. The method includes in vitro drug bioactivation models and quantitative-structure activity relationship (QSAR) studies.Courses taught
Research Interest
Chemical and biochemical aspects of drug or herbal constituents adverse reaction; Elucidation of drug or herbal constituents bioactivation that can lead to reactive and toxic metabolites; Cyctochrome P450-catalyzed drug or herbal constituents metabolism and toxicity; Synthesis of new drug analogues; Quantitative – structure activity relationships.
Expertise
Chemical and biochemical aspects of drug or herbal constituents adverse reaction; Phytochemical studies on anti-cancer, anti-malarial and anti-microbial bioactives. Elucidation of drug or herbal constituents bioactivation to reactive and toxic metabolites; Cyctochrome P450-catalyzed drug or herbal constituents metabolism and toxicity; Synthesis of new drug analogues; Quantitative – structure activity relationships.
Selected Publication
1. Mahmud R, Tingle MD, Maggs JL, Cronin MT, Dearden JC, Park BK. Structural Basis for the Haemotoxicity of Dapsone: The Importance of the Sulphonyl Group. Toxicology (1997), 117(1): 1 – 11.
Current Research
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