Vikneswaran a/l Murugaiyah

Discipline

Pharmacology

Courses taught

1. Semester I
   • FAR 341/4                   Respiratory, Renal & Blood System and Therapy
                                         (lecture & practical)
     

• FAR 342/3                   Cardiovascular System and Therapy
                                      (practical)
  

2. Semester II
   • FAR 142/3                   Basic Pharmacology and Biochemistry
                                         (practical)
     

• FAR 141/4                   Peripheral Nervous System and Therapy
                                      (practical)
  

• FAR 242/4                   Endocrine System and Metabolism
                                      (lecture)
  

• FAR 344/4                   Central Nervous System and Therapy
                                      (lecture & practical; also the course coordinator)
  

Research Interest

Drug discovery from natural products and synthesized organic compounds for neurodegenerative, metabolic and infectious diseases.

Expertise

Pharmacology, Phytochemistry, Analytical chemistry, Drug discovery

Consultation

• Analytical studies: Including development and validation of analysis methods, including phytochemical analysis of marker compounds and standardization of herbal extracts
• Animal studies: Pharmacological studies, acute, sub-chronic and chronic toxicity studies in mice, rats and rabbits
• In vitro and ex vivo testing: antimicrobial studies, enzyme inhibitory studies, antioxidant studies

• Pharmacokinetics testing: Bioavailability and pharmacokinetic studies of natural  products or synthetic compounds

Selected Publication

(a) International Journals

 

i.   Murugaiyah, V. and Chan, K.L. (2006) Antihyperuricemic lignans from the leaves of Phyllanthus niruri L. Planta Medica. 72, 1262-1267.

ii.  Murugaiyah, V. and Chan, K.L. (2007) Determination of four lignans in Phyllanthus niruri by a simple HPLC method with fluorescence detection. Journal of Chromatography A. 1154, 198-204.

iii.  Murugaiyah, V. and Chan, K.L. (2007) Analysis of lignans from Phyllanthus niruri L. in plasma using simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. Journal of Chromatography B. 852, 138-144.

iv.   Murugaiyah, V. and Chan, K.L. (2009) Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of Ethnopharmacology. 124, 233-239.

v.   Parthasarathy, S., Ramanathan, S., Ismail, S., Adenan, M.I., Mansor, S.M. and Murugaiyah, V. (2010) Determinationof mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat. Analytical and Bioanalytical Chemistry. 397, 2023-2030.

vi.   Krishnan, N., Ramanathan, S., Sasidharan, S., Murugaiyah, V. and Mansor, S.M. (2010) Antimicrobial activity evaluation of Cassia spectabilis leaf extracts. International Journal of Pharmacology. 6(4), 506-510.

 

(b) Local Journals

 

i.    Murugaiyah, V. and Chan, K.L. (2005) Xanthine oxidase inhibitory activity of some Malaysian plants. Malaysian Journal of Science. 24, 263-266.

ii.   Kuong, Y.M., Sadikun, A., Murugaiyah, V. And Asmawi, M.Z. (2010) Determination of Flavonoids and chlorogenic acid in Gynura procumbens by a simple high performance liquid chromatography method with ultraviolet detection (HPLC-UV). Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 9-10.

iii.   Beh, H.k., Seow, L.J., Asmawi, M.Z., Majid, A.M.S., Murugaiyah, V., Ismail, Z and Ismail, N. (2010) Antiangiogenic activity of Morinda citrifolia extracts and its chemical constituents. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 10-11.

iv.   Seow, L.j., Beh, H.K., Majid, A.M.S., Murugaiyah, V., Ismail, N. And Asmawi, M.Z. (2010) Antiangiogenic activity of Gynura segetum leaf extracts and its fractions. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 32.

v.   Koay, Y.H., Murugaiyah, V. And Chan, K.L. (2010) Evaluation of cholinesterase inhibitory activity of Phyllanthus niruri. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 44.

vi.   Aruldass, C.A., Ramanathan, S., Mansor, S.M. and Murugaiyah, V. (2010) Antimicrobial activity of methanolic extrcats of various parts of Mesua ferrea. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 45.

vii.  Marimuthu, M.M.,  Mansor, S.M., Murugaiyah, V. and Ramanathan, S. (2010) Antimicrobial activity of methanolic extracts of various parts of Ixora coccinea. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 46.

viii.  Lee, Y.E., Murugaiyah, V. and Chan, K.L. (2010) Acetylcholinesterase and butyrlcholinesterase inhibitory activities of Ailanthus malabarica and its fractions: A source for potential anti-alzheimer’s drugs. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 55-56.

ix.    Liew, W.L., Murugaiyah, V. and Chan, K.L. (2010) Inhibitory activities of Andrographis paniculata and its fractions on acetylcholinesterase and butyrlcholinesterase enzymes: A source for potential anti-alzheimer’s drugs. Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 56-57.

x.    Noormi, R., Subramaniam, S., Murugaiyah, V. and Sundarasekar, J. (2010) Qualitative determinations of potential lycorine alkaloid in Hymenocallis littoralis (Melong Kecil). Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 74.

xi.   Sandrasagaran, U.M., Ramanathan, S., Subramnaniam, S., Mansor, S.M. and Murugaiyah, V. (2010) Antimicrobial activity of Dendrobium crumenatum (Pigeon Orchid). Malaysian Journal of Pharmaceutical Sciences. Supp. 1, pg. 111-112.

Current Research

1. Studies on the mechanisms of antihyperuricemic activity, chronic toxicity and formulation of Phyllanthus niruri lignans for the development of potential antihyperuricemic agents.
   
   
2. Cholinesterase inhibitors from Andrographis paniculata and Phyllanthus niruri and their effects on memory and learning of the rodents.
   
   
3. Antihyperlipidemic and antioxidant activity of different parts of Garcinia atroviridis and elucidation of their mechanisms of action
   
   
4. Antihyperlipidemic and antioxidant of different parts of Garcinia mangostana
   
   
5. Cholinesterase inhibitors from Garcinia mangostana and their effects in Aß-induced neurotoxicity and on memory of the rodents.