Ezatul Ezleen

Discipline

Courses taught

• FAR 114/3 – Pharmaceutical Chemistry
• FAR 212/2 – Principles of Medicinal Chemistry
• FEL 373/2 – Drug Modeling

Research Interest

Drug design and discovery of anti-viral, anti-cancer and anti-obesity diseases

Expertise

1.Computer-aided drug design
Molecular docking, Virtual screening, Quantitative structure activity relationship (QSAR), Pharmacophore

2. Synthesis of molecules for application in therapeutic disease
Small molecule derivatives, Peptides, Photosensitizers

Consultation

NA

Selected Publication

1. Ludovic Colombeau, Ezatul Ezleen Kamarulzaman, Celine Frochot, Regis Vanderesse. Synthesis of Zinc 5-(4-propargylamidocarboxyphenyl)-10, 15, 20-triphenylchlorin. (2011) Trends in Organic Chem. 15, 33-40.
2. Thomas, N., Pernot, M., Vanderesse, R., Becuwe, P., Kamarulzaman, E., Da Silva, D., Francois, A., Frochot, C., Guillemin, F., Barberi-Heyob, M. (2010). Photodynamic therapy targeting neuropilin-1: Interest of pseudopeptides with improved stability properties. Biochem. Pharmacol. 80, (2), 226-235.

3. Ph. Huetz, E. E. Kamarulzaman, H. A. Wahab, and J. Mavri.  (2004) Chemical Reactivity as a Tool to Study Carcinogenicity: Reaction between Estradiol and Estrone 3,4-Quinones Ultimate Carcinogens and Guanine. J. Chem. Inf. Comput. Sci.  44, 310-314.

Current Research

1. Anti-viral
Design and synthesis of new drug derivatives for dengue and influenza diseases.

2. Anti-cancer
Design, synthesis, photophysical properties and biological evaluation of peptides-conjugated photosensitizer targeting neuropilin-1 for photodynamic therapy.

3. Anti-obesity
Hits to lead identification of potential medicinal plants targeting pancreatic lipase for anti-obesity properties.