Noratiqah Mohtar

Discipline

Pharmaceutical Technology

Courses taught

NA 

Research Interest

Development of pharmaceutical formulations using nanocarriers (e.g. lipid nanoparticles, cyclodextrin complexes) to improve the oral or pulmonary delivery of a drug.

Expertise

• Drug formulation development using techniques including homogenization, spray-drying and freeze-drying.
• Characterization of drug formulations for oral and pulmonary delivery using techniques such as dynamic light scattering, laser and X-ray diffraction, differential scanning calorimetry and the Next Generation Impactor.
• Development and validation of high performance liquid chromatography (HPLC) methods, for analysis of drug in formulation and plasma samples.
• In vitro cytotoxicity study on cancer cell line.
• In vivo pharmacokinetic study of oral preparation.

Consultation

NA

Selected Publication

Journals

1. Mohtar, N., Taylor, K. M. G., Sheikh, K., Somavarapu, S. (2017) Design and development of dry powder sulfobutylether-β-cyclodextrin complex for pulmonary delivery of fisetin. European Journal of Pharmaceutics and Biopharmaceutics, 113, 1-10.

2. Mohtar, N., Khan, N. A. K., Darwis, Y. (2015) Solid lipid nanoparticles of atovaquone based on 24 full-factorial design. Iranian Journal of Pharmaceutical research, 14(4), 989-1000.

3. Mohtar, N., Khan, N. A. K., Darwis, Y. (2015) A simple HPLC-UV method for quantification of atovaquone in rabbit plasma. Journal- Indian Chemical Society, 92, 1491-1497.

4. Febriyenti, F., Mohtar, N., Mohamed, N., Hamdan, M. R., Salleh, S. N. M., Baie, S. (2014) Effect of freeze drying and spray drying processes to amino acids and fatty acids contents in Haruan (Channa striatus) extract. International Journal of Drug Delivery, 6 (3), 301-304.

5. Febriyenti, F., Mohtar, N., Mohamed, N., Hamdan, M. R., Salleh, S. N. M., Baie, S. (2014) Comparison of freeze drying and spray drying methods of Haruan extract. International Journal of Drug Delivery, 6 (3), 286-291.

6. Khan, A. A., Mudassir, J., Mohtar, N., Darwis, Y. (2013) Advanced drug delivery to the lymphatic system: lipis-based nanoformulations. International Journal of Nanomedicine, 8, 2733-2744.

Conferences

1. Mohtar, N., Taylor, K., Somavarapu, S. (2018, November). Inhalable formulation of fisetin and erlotinib for the treatment of non-small cell lung cancer. 7th International Conference on Biotechnology for the Wellness Industry, Kuala Lumpur, Malaysia.

2. Mohtar, N., Taylor, K., Somavarapu, S. (2017, December). Erlotinib-fisetin-SBE-β-CD complex for pulmonary delivery as an improved treatment for non-small cell lung cancer (NSCLC). Drug Delivery to Lungs Conference, Edinburgh, U. K.

3. Mohtar, N., Taylor, K., Sheikh, K., Somavarapu, S. (2016, September). Production of a dry powder sulfobutylether-β-cyclodextrin (SBE-β-CD) complex for pulmonary delivery of fisetin. APS 7th International PharmSci Conference, Glasgow, U. K.

4. Mohtar, N., Taylor, K., Sheikh, K., Somavarapu, S. (2015, October). Sulfobutylether-β-cyclodextrin (SBE-β-CD) fisetin complex dry powder formulation for lung delivery. AAPS Annual Meeting and Exposition, Florida, U. S.

Current Research

  NA