Research Interest

• Immunopharmacology
• Innate immunity and Inflammation
• Tumour-promoting and -associated inflammation
• Drug discovery from natural products for inflammation-induced diseases
• Cross-talk interactions of signalling pathways modulating inflammation, autoimmune disorders and tumorigenesis

On-going Research

• Elucidating Mechanistic Role of Signalling Pathways in Regulation of Tumour-Associated
  Macrophages and Hepatocellular Carcinoma Microenvironment

• Phytochemical Profiling and Anti-inflammatory Evaluation of Annonaceae Species

1. Acute inflammation and tumour-promoting inflammation modelling
2. Acute cytotoxicity, mutagenicity and genotoxicity analysis of non-pharmaceutical products
3. Epigenetic programming and reprogramming of immune cells in the tumour microenvironment
4. Discovery and preclinical evaluation of natural products with potential anti-inflammatory activities

1. Afzal, S., Abdul Manap, A.S., Attiq, A., Albokhadaim, I., Kandeel, M., Alhojaily, S.M., 2023. From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration. Front. Pharmacol. 14, 1269581.

2. Attiq, A., and Afzal, S., Trinity of inflammation, innate immune cells and cross-talk of signalling pathways in tumour microenvironment. Front. Pharmacol. 14

3. Afzal, S., Sattar, M.A., Eseyin, O.A., Attiq, A., Johns, E.J., 2022. Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs. European Journal of Pharmacology 917, 174703.

4. Attiq, A., Jalil, J., Husain, K., Mohamad, H.F., Ahmad, A., 2021. Luteolin and apigenin-derived glycosides from Alphonsea elliptica abrogate LPS-induced inflammatory responses in human plasma. Journal of Ethnopharmacology 275, 114120.

5. Attiq, A., Jalil, J., Husain, K., Jamal, J.A., Ismail, E.N., 2021. A new prenylated benzoquinone from Cyathocalyx pruniferus abrogates LPS-induced inflammatory responses associated with PGE2, COX-2 and cytokines biosynthesis in human plasma. Inflammopharmacology 29(3), 841-854.

6. Attiq, A., Yao, L.J., Afzal, S., Khan, M.A., 2021. The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19. International Immunopharmacology 101, 108255.

7. Afzal, S., Sattar, M.A., Johns, E.J., Eseyin, O.A., Attiq, A., 2021. Antioxidant Potential of Adiponectin and Full PPAR-γ Agonist in Correcting Streptozotocin-Induced Vascular Abnormality in Spontaneously Hypertensive Rats. PPAR Research 2021, 6661181.

8. Puah, B.-P., Jalil, J., Attiq, A., Kamisah, Y., 2021. New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene. Molecules 26(13), 3888

9. Jalil, J., Attiq, A., Hui, C.C., Yao, L.J., Zakaria, N.A., 2020. Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation. Inflammopharmacology 28(5), 1195-1218.

10. Yao, L.J., Jalil, J., Attiq, A., Hui, C.C., Zakaria, N.A., 2019. The medicinal uses, toxicities and anti-inflammatory activity of Polyalthia species (Annonaceae). Journal of Ethnopharmacology 229, 303-325.

11. Attiq, A., Ashraf, M., Jalil, J., Javeed., Augmented cytotoxic, mutagenic and genotoxic response triggered by carvedilol and celecoxib combinations. Brazilian J Pharmaceutical Sciences 54(1)

12. Attiq, A., Jalil, J., Husain, K., Ahmad, W., 2018. Raging the War Against Inflammation With Natural Products. Frontiers in Pharmacology 9.

13. Attiq, A., Jalil, J., Husain, K., 2017. Annonaceae: Breaking the Wall of Inflammation. Frontiers in Pharmacology 8.

14. Ullah, A., Ashraf, M., Javeed, A., Anjum, A.A., Attiq, A., Ali, S., 2016. Enhancement of anti-proliferative activities of Metformin, when combined with Celecoxib, without increasing DNA damage. Environmental Toxicology and Pharmacology 45, 227-234.

15. Raja, S., Ashraf, M., Anjum, A., Javeed, A., Ijaz, T., and Attiq, A. Antibacterial activity of essential oils extracted from medicinal plants against multi-drug resistant Staphylococcus aureus. 

1. FAR132/3 Basic Physiology and Pharmacology
   (lectures & practical)

2. FAR162/2 Principles of Immunology and Oncology
   (lecture; also the course coordinator)

3. FAR 344/4 Central Nervous System and Therapy
   (lecture & practicals)