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Potential New H1N1 Neuraminidase Inhibitors from Ferulic acid and Vanillin: Molecular Modelling, Synthesis and in vitro assay

Maywan Hariono, Nurshariza Abdullah, K.V Damodaran, Ezatul E. Kamarulzaman, Nornisah Mohamed, Syarifah Syed Hassan, Shaharum Shamsuddin and Habibah A. Wahab

Scientific Reports (2016) Volume 6, Article No 38692

This paper reported a combination of computational and experimental studies in the design of novel neuraminidase (NA) inhibitors from vanillin and ferulic acid scaffolds. NA is an enzyme which is important in H1N1 virus and currently, there are two commercially available inhibitors for this virus, namely the oseltamivir and zanamivir. The work presented in this paper is of high value as there are potential in developing the two derivatives into an effective NA inhibitor, especially from ferulic acid which had shown an EC₅₀ of 0.95 uM from in vitro assay.

Further information, visit https://www.nature.com/articles/srep38692